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However, Wilson follows him and finds him puking it up out back by a dumpster, House finally admits he is taking Methadone because it has put an end to the pain in his leg. After threatening to leave if Cuddy won't agree to methadone treatment, he instead goes back to Vicodin because his changed behavior with methadone almost cost a patient his life. Thirteen has to confront the reality, forced upon her by Amber's death at an early age, that she too is facing a lifetime with a devastating illness. Her behavior quickly starts to deteriorate and she is fired and then re-hired.
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House and the team plan to get the man into the hospital for surgery without causing any problems. Meanwhile, Cameron and Chase attempt to work through issues in their relationship, and House deals with an annoying itch he cannot seem to scratch, with Wilson making his own analogies about the problem. They put the patient in a hyperbaric chamber to work the air out of his system. Cuddy calls the team over to her house to punish them for letting the patient attempt suicide. Thirteen wants to focus on the abdominal pain, which was the first symptom. He's seen several doctors but none have found what ails him.
Airdate
Cuddy finds that taking care of her newly adopted baby leaves her little time to run a hospital and babysit House at the same time. At Cameron's urging, the team takes the case of a suicidal man (Martin Henderson) who suffers from excruciating chronic pain—pain that mirrors House's. Chase and Cameron start getting more serious about their relationship.
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House thinks it's drug seeking behavior, but Cameron points out the patient had narcotics and didn't even use them to try to commit suicide. Cameron dismisses Thirteen's diagnosis of fibromyalgia and Taub's guess that it's mental illness. None of the patient's previous doctors have found anything wrong with him.
Final diagnosis
He talks about epilepsy and how it might affect the muscles affecting the testicles. Because the control of those muscles are deep in the brain, a seizure wouldn't show up on an EEG or show neurological symptoms. He confronts the patient - the pain didn't start in the stomach, but lower down. They start treating the patient for epilepsy and he slowly improves.
Painless
House comes to work in a good mood, setting everybody off. Wilson and Foreman conclude that House is taking heroin. Wilson takes House out to dinner and buys him a drink, and after House drinks it, he walks off indignant that Wilson would suspect that he is taking heroin.
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While Thirteen and Kutner work on it, the patient has great pain in his right arm and goes into cardiac arrest. A man tries to commit suicide by inhaling carbon monoxide, but his wife and son come home early and rescue him. Five seasons in, Hugh Laurie continues to find new emotional wrinkles to the complicated character that is Doctor House. After Chase recovers, he and Cameron continue with their wedding plans. Cameron reveals that she was keeping a frozen sample of her deceased first husband's sperm in case she never found a new person but still wanted to have children. They finally compromise with Chase agreeing she can keep the sample.
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Gill of The Sunday Times felt that the show had "lost its sense of humour". Maureen Ryan of the Chicago Tribune wrote, "House used to be one of the best shows on TV, but it's gone seriously off the rails". House goes to take a bath and realizes that he's been pulling on the pipes to help himself in and out of the bath and realizes that he actually did cause the damage to his own pipes. House burns part of his kitchen to get his insurance to pay for the pipes above it, quoting verbatim from the insurance policy. They inject the patient with naloxone, a drug that blocks opiates. The patient loses most of his pain under anesthetic, but not all of it.
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When they learn that the patient gave up her career as a highly renowned cancer researcher in order to pursue her own personal happiness, the members of the team question their own happiness (or lack thereof). Meanwhile, Thirteen begins to suffer serious and life-threatening reactions to her experimental Huntington's disease clinical drug trial, and Cuddy retaliates against House and gives him a taste of his own medicine. A painter's (Breckin Meyer) undiagnosed illness begins to affect his work, but he is unable to see his art is suddenly grotesque.
As House sees the handyman pack up, scratching at his crotch as he does so, he gets an idea. The place is a disaster because her maid's late, and Cuddy ditched one of Rachel's diaper in her briefcase in a panic. However, the agency man is impressed anyway by her job, stability, and general embarrassment of the mess. He tells her she's way above most foster moms and will see her next year if she hasn't adopted by then. However, Wilson has to come to terms with another loss - his homeless brother Danny reappears in his life when he is found in New York City. Wilson finds that Danny is now a stranger to him and that the initial incident that led to his disappearance has shaped his behavior in ways only House seems to fully comprehend.
Unable to cope, Wilson resigns from the hospital, while Cuddy desperately tries to get him and House to repair their shattered friendship. Meanwhile, Thirteen struggles with her own diagnosis of Huntington's and helps to treat an executive assistant (Christine Woods) with a similar personality to her own. House's father dies, and House tries to dodge the funeral, only to have Wilson return as a favor to Cuddy and Blythe House to ensure that House makes it. During the trip, the details of the beginnings of their friendship are revealed. House also reveals that he suspected John House wasn't his biological father and House points out a family friend at the service who House believes really is his father. After they return to Princeton, Wilson realizes he hadn't had this kind of fun since the day Amber died and decides to return to Princeton-Plainsboro.
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House and the team are given the challenging case of a ballerina (Jamie Tisdale) whose lungs collapse during a rehearsal. After first facing the prospect of never dancing again, the ballerina's future seems even more grim when the treatment causes her skin to fall off. House must solve this daunting puzzle while going to desperate measures to cure his hallucination; he continues to suffer from a severe lack of sleep and is still haunted by Amber. While enlisting Wilson's help to diagnose himself, he is willing to do the unthinkable to make his visions stop.
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